First Look: FOX’s 9/20 “Scream Queens” Season Two Premiere Hopes You’ll “Scream Again”

While not a live+same-day ratings force, season one of FOX’s “Scream Queens” did receive a solid boost from DVR viewership.

It, more notably, generated ample buzz on social networks.

FOX is hoping season two will also prove resonant. It will find out whether that hope becomes reality on September 20, when the second season of “Scream Queens” premieres.

Entitled “Scream Again,” the premiere finds the series — and many of its key first season cast members — shifting to a mysterious hospital.

In advance of the September 20 premiere, FOX shared a synopsis, cast list and production photos for the episode. All follow (note: if you’re viewing the AMP version of this page, you may have trouble viewing the photos. Click here to view the gallery).

Years after the murderous events at Kappa House, Dean Munsch purchases an abandoned hospital under the guise of fixing the healthcare system in America. After recruiting surgeons, Dr. Brock Holt and Dr. Cassidy Cascade, as well as medical student Zayday Williams, the Dean shocks everyone when she enlists the services of the disgraced Chanels to join the ranks at the teaching hospital. Meanwhile, secrets from the hospital’s past begin to reveal themselves and a new killer surfaces in the all-new “Scream Again” season premiere episode of SCREAM QUEENS airing Tuesday, Sept. 20 (9:01-10:00 PM ET/PT) on FOX. (SQ-201) (TV-14 D, L, S, V)

Cast: Emma Roberts as Chanel Oberlin; Jamie Lee Curtis as Dean Cathy Munsch; Lea Michele as Hester; Abigail Breslin as Chanel #5; Billie Lourd as Chanel #3; Keke Palmer as Zayday Williams; John Stamos as Dr. Brock Holt; Taylor Lautner as Dr. Cassidy Cascade; James Earl as Chamberlain Jackson

Guest Cast: Niecy Nash as Denise Hemphill; Cecily Strong as Catherine Hobart, Jerry O’Connell as Dr. Mike; Laura Bell Bundy as Nurse Thomas; Jeremy Batiste as Bill; Trilby Glover as Jane